hrp0097p1-407 | Adrenals and HPA Axis | ESPE2023

17OHP levels to diagnose Non-Classic Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency (NC-CAH) in children with precocious pubarche

Chagas Nathália , Aragon Davi , Mermejo Livia , de Castro Margaret , Moreira Ayrton , Antonini Sonir

Background: Basal 17OHP levels to indicate an ACTH-stimulation test and post-ACTH 17OHP cut-off levels diagnosing NC-CAH vary among different guidelines.Objective: To establish the performance of basal and post-ACTH 17OHP concentrations for the NC-CAH diagnosis in children with precocious pubarche (PP).Methods: Clinical, biochemical, and molecular analysis from 202 PP patients subm...